Cambridge scientist ‘on verge of curing multiple sclerosis’

A researcher from Cambridge University, UK, has made a discovery which could lead to a cure for multiple sclerosis. What’s more, she says it can tackle other diseases too.

LIF

Dr Su Metcalfe of LIFNano (Photo David Johnson).

Dr Su Metcalfe was working at the university’s department of surgery when she made her big breakthrough. “I was looking to see what controls the immune response and stops it auto-attacking us,” she told the Cambridge News.

It all revolves around a stem cell particle called a LIF.

She explained: “I discovered a small binary switch, controlled by a LIF, which regulates inside the immune cell itself. A LIF is able to control the cell to ensure it doesn’t attack your own body but then releases the attack when needed.

“That LIF, in addition to regulating and protecting us against attack, also plays a major role in keeping the brain and spinal cord healthy. In fact, it plays a major role in tissue repair generally. It turns on stem cells that are naturally occurring in the body.”

It is a natural regenerative medicine, and plays a big part in repairing a damaged brain.

Stopping and reversing disease

“So, I thought this is fantastic. We can treat autoimmune disease, and we’ve got something to treat MS, which attacks both the brain and the spinal cord. It’s a double whammy that can stop and reverse the autoimmunity (disease), and also repair the damage caused in the brain.”

There was a problem, though. The LIF only survives outside the cell for 20 minutes before it is broken down. This meant there was not enough time to deploy it in a therapy.

The answer turns out to be nano-particles.

The particles were developed at Yale University, USA. Yale is listed as co-inventor with Su, but LIFNano has the worldwide licence to deploy them.

Su says: “Nano-medicine is a new era, and big pharma has already entered this space to deliver drugs while trying to avoid the side effects. The quantum leap is to actually go into biologics and tap into the natural pathways of the body.

“We’re not using any drugs, we’re simply switching on the body’s own systems of self-tolerance and repair. There aren’t any side effects because all we’re doing is tipping the balance. Auto-immunity (diseases) happen when that balance has gone awry slightly, and we simply reset that. Once you’ve done that, it becomes self-sustaining and you don’t have to keep giving therapy, because the body has its balance back.”

LIF clinical trials

LIFNano has already attracted two major funding awards, from drug firm Merck and government agency Innovate UK. Su has recruited chairman Florian Kemmerich and ceo Oliver Jarry, both with experience in the pharma sector. The company hopes to attract more investment, with the aim of starting clinical trials in 2020.

“The 2020 date is ambitious, but with the funding we’ve got and the funding we’re hoping to raise, it should be possible,” says Su.

What’s in store for LIFNano after MS?

“MS is our key driver at the moment, but it’s going to be leading through to other major auto-immune disease areas,” Su answers

“Psoriasis is high up on our list, and diabetes is another. Downstream there are all the dementias, because a LIF is a major health factor for the brain. So, if we can get it into the brain we can start protecting against dementia.”

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Affiliate disclaimer: This affiliate disclosure details the affiliate relationships of MS, Health & Disability at 50shadesofsun.com with other companies and products. Read more.

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50shadesofsun.com is the personal website of Ian Franks, a Features Writer with Medical News Today. He enjoyed a successful career as a journalist, from reporter to editor in the print media. He gained a Journalist of the Year award in his native UK. Ian received a diagnosis of MS in 2002 and now lives in the south of Spain. He uses a wheelchair and advocates on mobility and accessibility issues.

8 thoughts on “Cambridge scientist ‘on verge of curing multiple sclerosis’

  1. 2015 me and my husband suffered from LUPUS(chronic autoimmune disease). it happened a few months after i got married to my husband. i found out that i got LUPUS and i was confirm positive and was perplexed, so angry and then i had to convince my husband to go test himself and when he did, he was also found positive and then it was dawn completely on me that me and my husband is having LUPUS . i went out in search of a solution despite my doctor told me that there was no remedy to curing me and my husband LUPUS . When i was searching, i found out there so many testimonies about perfect health herbal medicine home helping others to be cured of LUPUS (chronic autoimmune disease) . I instantly write down their email and purchase herbal medicine for lupus (chronic autoimmune disease),then they sent the herbal medicine to us through courier service,when i received the herbal medicine, I used it as he instructed

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    • I wish you luck but the expense of trying every semi plausible miraculous treatment for M.S. has been enormous since I was diagnosed in 1992.

      There are hordes of well meaning or deliberately dishonest crooks all to willing to take your money forever with little to show for it. Empty promises that can be downright dangerous depending on the safety on the substance they’re peddling.

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  2. I was diagnosed with multiple sclerosis 1 month after I turned 50. My was is 96 and had it since she was in her 20s. I was on Copaxone, the first year was daily and later I was on 40 mg, 3 times a week. It made a tremendous difference for me. Although the fatigue was what really gets to me. When I do too much, I do start to feel weak.There has been little if any progress in finding a cure or reliable treatment. My multiple sclerosis got significantly worse and unbearable because of my cognitive thinking.. Last year, i started on a natural multiple sclerosis Herbal therapy from Green House Herbal Clinic, i read a lot of positive reviews from patients who used the treatment and i immediately started on it. I had great relief with this herbal treatment. I am doing very much better now, no case of Cognitive thinking or memory Loss,, my multiple sclerosis condition is totally reversed. Visit Green House Herbal Clinic website

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  3. I was having joints pain in both hands inside and outside and muscle weakness due to multiple sclerosis (MS). I was falling a lot, I had headaches and lightheadedness. I couldn’t keep myself balanced, and walk with a tremor like I cannot control my steps. The amantadine hydrochloride (Symmetrel®) and modafinil (Provigil®) did very little to help me. I still didn’t feel any better, Since the original diagnosis, My stiffness has slowly increased. October 2017 my brother in-law told us about Natural Herbal Gardens where he ordered herbs that effectively treated his Parkinson’s. We ordered their multiple sclerosis herbal treatment after reading alot of positive reviews, i am happy to report this multiple sclerosis herbal treatment reversed my (MS) condition. My quality of life has greatly improved and every one of my symptoms including muscle weakness and tremors are gone. Their official web official website is I can now go about my daily activities, I will be 64 soon.

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  4. Been diagnosed with multiple sclerosis in 2015, and I was a woman of 50. They put me on Rebif which I took until 2017 and was switched to Copaxone. I had two relapses on Rebif, none so far on Copaxone. I do notice my balance was getting worse, and my memory, as well as erectile dysfunction and spasms’ had no choice to sick for other solution and I was introduce to totalcureherbsfoundation .c om which I purchase the MS herbal formula from the foundation, the herbal supplement has effectively get rid of my multiple sclerosis and reversed all symptoms. 

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